Inter-individual Variability of Coumarin 7-hydroxylation (CYP2A6 activity) in an Iranian Population
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inter-individual variability of coumarin 7-hydroxylation (cyp2a6 activity) in an iranian population
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متن کاملInter-individual Variability of Coumarin 7-hydroxylation (CYP2A6 activity) in an Iranian Population
OBJECTIVE(S) Coumarin hydroxylase (CYP2A6) is a polymorphic enzyme, and during the last decade has received a lot of attention because it is the principle human nicotine C-oxidase, which activates a number of procarcinogens, and metabolizes drugs. MATERIALS AND METHODS 150 healthy Iranian volunteers, (96 male, 54 female) aged 19 to 63 years old, were given 5 mg coumarin orally after an overni...
متن کاملFunctional Characterization of 34 CYP2A6 Allelic Variants by Assessment of Nicotine C-Oxidation and Coumarin 7-Hydroxylation Activities.
CYP2A6, a member of the cytochrome P450 (P450) family, is one of the enzymes responsible for the metabolism of therapeutic drugs and such tobacco components as nicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and N-nitrosodiethylamine. Genetic polymorphisms in CYP2A6 are associated with individual variation in smoking behavior, drug toxicities, and the risk of developing several cancer...
متن کاملAnalysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis.
Cytochrome P450 (P450) 2A6 is an important human enzyme involved in the metabolism of many xenobiotic chemicals including coumarin, indole, nicotine, and carcinogenic nitrosamines. A combination of random mutagenesis and high-throughput screening was used in the analysis of P450 2A6, utilizing a fluorescent coumarin 7-hydroxylation assay. The steady-state kinetic parameters (k(cat) and Km) for ...
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1 Title: Predictors of variation in CYP2A6 mRNA, protein, and enzyme activity in a human liver bank: influence of genetic and non-genetic factors Authors: Julie-Anne Tanner, Bhagwat Prasad, Katrina G. Claw, Patricia Stapleton, Amarjit Chaudhry, Erin G. Schuetz, Kenneth E. Thummel, Rachel F. Tyndale Author Affiliations: Campbell Family Mental Health Research Institute, Centre for Addiction and M...
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عنوان ژورنال
دوره 16 شماره 4
صفحات 610- 614
تاریخ انتشار 2013-04-01
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